Studies on leukocyte phosphatases. II. Inhibition of leukocyte alkaline phosphatase by amino acids and its reversal by zinc.

نویسندگان

  • L R DeChatelet
  • J V Volk
  • C E McCall
  • M R Cooper
چکیده

The activity of leukocyte alkaline phosphatase is inhibited by a number of amino acids, most notably cysteine and histidine. The mechanism of this inhibition involves chelation of Zn2+ by the amino acids, as indicated by the complete reversal of the inhibition by added Zn2+. The concentrations of amino acids and Zn2 required to affect the enzyme activity are such that their interaction might represent an in vivo mechanism for the control of leukocyte alkaline phosphatase activity.

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عنوان ژورنال:
  • Clinical chemistry

دوره 17 3  شماره 

صفحات  -

تاریخ انتشار 1971